Abra(xane) Cadabra

17 Mar

The thought of changing treatments conjures up mixed emotions. I haven’t come across too many people who deal well with changes for the unknown – and if I have, I’ve forgotten the ground rules. So trepidation will be there but Tarceva, with its unpleasant side effects, won’t. Abraxene in – but will it work its magic?

We all know Abracadabra is an incantation used as a magic word in magic tricks. Historically it was believed to have healing powers when inscribed on an amulet. The word is thought to have come from “אברא” (avra) meaning “I have created” and “כאדאברה” (k’adabra) meaning “as I speak”.

Abraxane was first sold in the United States by Abraxis Bioscience in 2005 for breast cancer. It’s a protein-bound paclitaxel, a mitotic inhibitor drug used primarily in the treatment of breast cancer. Abraxane is a first in its class of drugs using nanoparticle albumin bound (nab) technology platform. In June 2010, positive results were published from a phase III trial in first-line non-small-cell lung cancer (NSCLC). Some pancreatic patients have been on it for a while now, and are doing well.

So why the change? We’ve always tried to “keep ahead of the game”. Out- guess the cancer (and maybe the oncologists?). Why the trepidation? Who knows what will happen. They say one of Abraxane’s side effects is hair loss – and I can’t say that fills me with great joy. The truth is that while on Gemcitobene and Tarceva something has changed, both physically and psychologically – and I can’t put my finger on it.

Hopefully writing about abraxane, then trying it, will do the trick.

Or should I just say Abra(xane) Cadabra, and hope for the best?

One Response to “Abra(xane) Cadabra”

  1. Karen Abel March 19, 2012 at 4:20 pm #

    Once again you’re a brave man and here’s hoping that the “magic” of the change of medicine works wonders for you despite some unpleasant side effects.
    We are all hoping (and some are praying!) for the best for you, dear Martin 🙂

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